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We aim to develop functional biomaterials for the cure of various disorders.
Especially, we consider that we want to contribute to the cure of “ intractable diseases ”.


How do you answer when you are asked as follows ?

“ How method do you consider to cure disorders ? ”

Probably, everyone will answer “ I use the drug which matches the symptom. ” and “ I cure the disorder by the operation (surgery) ”.
Almost people don’t consider and answer “ Use biomaterial ”.

But!! Biomaterials exist in our immediate surroundings.
For instance, an adhesive plaster (「ばんそうこう」 in Japanese) and a packing sheet (「しっぷ」 in Japanese)
are one of biomaterials. We have been already used various biomaterials.
However, the word of “ Biomaterial ” doesn’t permeate to the general public.

Recently, “Regenerative medicine” is famous for the dominant method to cure the intractable diseases.
The " induced pluripotent stem cells (iPSCs) " are considered as one of the main tools of regenerative medicine
such as " cell transplantation therapy " and " cell-based therapy ".
However, various disorders cannot be cured only by the use of iPSCs.
On the therapy using cell, biomaterials are necessary to protect and control cells in the body.


Research and Development of Bio-active and Bio-inactive materials.

Design of functional materials possessing specific bioactivity.

Bio-active materials are the functional devise to repair and regenerate an affected area by the strict regulation of cells and tissues. Key components for designing bio-active materials is “ Chimeric protein ” (a.k.a. fusion protein) which is protein having several functional domains and “ Hydrogel ” which is composed of synthetic polymer and biopolymer. By conjugating two components, we design the “ Functional Hydrogel ”.

Design of gentle materials against the body and tissue using bio-inert polymers.

Bio-inactive materials are that the materials not to interact to various biomolecules such as proteins and cells. We focus on “zwitterionic form” and "charge neutralization" that are known as bio-inert and anti-biofouling. By using polymer materials possessing zwitterionic group or charge neutral domain, functional biomaterials are designed and developed.

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Nakaji Laboratory was set up in Faculty of Engineering and Graduate School of Science and
Engineering of Education, University of Toyama at April, 2015.

The objects of our laboratory are (1) the development of novel highly-functional biomaterial,
and (2) the cultivation of the “ researchers ” or “ engineers ” for biomaterial development.
And our final goal is the design of “ Ultimate Weapon ” for medical doctors which try out the
cure of intractable disorders.

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